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Before taking this medicine You should not be treated with this medicine if you are allergic to prostaglandins, or if you have: • active genital herpes with a vaginal lesion; • placenta previa (the placenta is below the fetus in your uterus); or • if your water has broken. Be sure your doctor knows your entire pregnancy history, especially: • if you have ever had a or major surgery on your uterus; • if you have ever had a baby born in a breech position (not head-first); or • if you have ever had a difficult labor or delivery of a previous child. To make sure dinoprostone is safe for you, tell your doctor if you have ever had: • liver or kidney disease; •; •; • if you are 30 years or older; or • if your pregnancy is at full term (40 weeks). Dinoprostone is not expected to be harmful to the unborn baby when used to induce labor.

How is Prostin E2 given? Dinoprostone is a gel or suppository that is placed directly onto the cervix through the vagina using a special applicator. A healthcare provider will give you this medication. Dinoprostone is usually given while you are lying on your back. Your doctor may use a vaginal speculum to view your cervix. This will help your doctor determine how much of this medication to use. You will need to remain lying down for at least 15 minutes unless your doctor tells you otherwise.